Awesome reply. That is, to me, the problem of shooting game animals that far. They can move a lot and if the first shot didn't drop them, it is not going to be easy to guess which way they move and lead the target.
As for blood trails, that is why that little crow guy prefers copper mono, even at 300 yards and in. Because they tend to cause an exit wound and that helps with lung collapse and exsanguination. He has said that he has seen ELD-X bullets enter and not leave and the bull (elk) saunters off.
And deer have been wounded at less than 100 yards. I may never shoot past 400 yards and 300 yards is my comfort zone, for now.
But you are right. Even with the practice of going to where the animal was when you shot it and then track in the direction he ran, It is still quite a task. But I get, out west, the shots are longer. Even in my state, in the western part, they have mule deer hunts and you are advised to be able to shoot at least 200 yards and you will be dealing with cold and winds in a canyon.