For the 6.5CM, 260 Rem, or 308, I'd be adding in the 20MOA slope to the mounting setup.
For 223/5.56, or 6.5 Grendel, probably not; because I want to stay within realistic performance expectations from the combination of the chambering and my own abilities.
I don't want or need to use these chamberings beyond MR distance, 600 or so yards. I doubt I'd be able to handle wind calls/corrections for them beyond 600-800yd, and by the time they're out there, even with a good hit, terminal performance becomes questionable, IMHO.
For shots beyond that, I've got 260 and 308 platforms, and they'd carry the mail decisively.
IMHO it's about choosing the right tool for the job, and employing a decisive advantage within that environment.
Greg