I have my cant stacked.
I use the same scope, Cronus, mainly between 22LR Quad and 223 AR.
The scope mount is 6mil/20moa and the Quad has another 6mil on the picatinny rail.
This has worked VERY well since it gives much better image down range at farther targets and these two guns have zero within 0.5mil at 50m for 22lr and 100m for 223.
My argument is that for regular rifle cartridge 6mil is quite plenty. But for 22LR, no way in hell it is enough, it drops like a stone.
My view on it is:
With modern scope alone, 330yds is at near max.
Add 6mil/20moa and you get 400yds
Another 6mil and you get to around 460yds.
My max targets have been around 420 and if I remember correctly I still needed to hold because of cold weather. That distance has so far been the most fun and interesting to ever shoot, I have been there after that too.