Re: .22LR Zero
the mildots are nice for that, the catch is if you don't have the reticle on the first focal plane, the POI will change when, or if, you change your magnification level and shoot. as long as you keep it at the same magnification, it'll work.
you can do the same with duplex styled reticles and target dots doing a 6 o'clock or twelve o'clock hold (depending on magnification settings)
but if you don't have the mildots and holdover / under plus magnification settings starts getting too complicated / confusing, you are back to square one. which is why i generally use turret adjustment. just "set a # and squeeze a trigger" is simple to remember no matter what magnification setting your on.