I have a Savage 93R17 BTVS and a Ruger American Target in .17 HMR, a Savage B-mag in .17 WSM, and looking for a bolt gun in .17 HM2 to replace my Ruger 10/22 that was converted to .17 HM2 and became unreliable. I've shot thousand of sage rats with the HMR and hm2 which had replaced my Ruger M77/22 mag about 10 years ago. The laser accuracy of a good HM2 is hard to argue from 25-150 yds, the HMR is not that much better from 25-125, but beyond 125 out to 225 it flexes is muscle in my experience. The .17 WSM hit quite a bit harder than the HMR and it's accuracy appears to be similar.
The .22 LR just doesn't do much for me sage rat hunting. Too much time calculation/guesstimating hold-overs when targets abundant. It also wounds more than kills allowing the squirrel to hole up thus taking food away from the beneficiaries of our Raptor Feeding Program.
If I could only have one .17 it would be the .17 HMR. If I could only have two they would be the HM2 and WSM. Thankfully I can have 3+ because they are very fun, effective, and affordable to shoot.
At the range I shoot more .22 lr than anything else and thoroughly enjoy it. Ringing 10" round steel at 300 yds consistently with a suppressed .22 just makes me grin.
But if I could only have one rimfire it would be the .17 HMR.
My Ruger American .17 HMR in it's happy place: