An individual would really need to test it out side by side with and without to see if there is a tangible difference. My biggest variable for now is probably the accuracy of my mechanical scale. I am waiting on an Auto Trickler to reduce the scale variance, speed will be a bonus.
For myself, I do use the Sinclair PPU to remove another potential variable in the brass. It is an extra step, I also use a K&M flash hole uniformer, another extra step.
For my own "feels" is probably the best reason why I do it, thinking if I remove as many variables as possible that I can control, it may improve the performance of my handloads.
It's not always enjoyable, especially sitting down and doing 200+ cases. Case trimming on a Wilson is probably the worst part of my case prep. A drill press with the PPU in it is the easiest part.
I put the effort into case prep on once fired brass so I know they are as uniform as possible, short of weight sorting.
I haven't spent the money on Lapua or other premium brass, I shoot mostly Hornady or FGMM factory and then reuse the cases for my purposes. Factory Match ammo is usually my baseline for performance in both checking out a rifle as well as eeking out a better group on the reloading bench.