I like the .30-'06; its recoil is more tolerable for longer shooting sessions, and that's mandatory for my first mantra, know your gun. I make up 125gr loads for extended practice.
Some heavier weight loads closely approach the terminal performance of the 300WM. Which one is a matter of choice. As a meat hunter, I'm conscious of meat damage; and I prefer the .30-'06 180gr load for longer, and the 165gr loads for shorter distances.
Bonded bullets all the way. My ammo choice is Hornady American Whitetail, with Remington Core-Lokt when the very best is better than I actually need. They are both effective meat gatherers.
My belief is that the .30-'06 should be clearly adequate for North American Big Game; and that when the '06 is beyond its capacity, usually, the shooter is as well. It's one chambering that should always be available on the road.
If I'm shooting Big Game beyond 300yd, I'm generally out of my usual woodland element. My bedded 30-'06 M70 Featherweight and 168gr FGMM brought me a 4th in the NJ State Sniper Championships in 1997, a 300yd match. Lightweight guns can often shoot a lot better than most credit them, but that combination in 300WM would not work for me. The Featherweight has been heirloomed down to my SIL, who has already harvested 3 deer with it this year in Central NY..., so far...
One main thing to consider about reaching way out and touching has to about how one is going to go about retrieving one's kill. At 73, that's a crucial one for me, and 300yd is actually becoming LR for hunting.
People are starting to say, "S'OK Greg, we'll get that...", and I'm about ready to agree...
Greg