Seems like there are a couple methods to use a switch barrel rifle.
Dead on accurate - Multiple barrels all expected to be absolutely zeroed after a barrel change (after scope adjustments). These guys are probably better off having multiple rifles and if cost is a limitation, they should have two rifles with one being a performance rifle and one being a "trainer" be it a 223, 308, 300 Win, or something else with ammo that is reasonably priced. Seems like the ideal world for these guys is they can save on new "guns" by only buying another barrel and forget the cost to stock enough ammo for their 15 calibers, BUT at least they own a single rifle.
Accurate enough - A couple barrels are good enough for these guys and each provides a true differentiated capability. They don't mind taking the time to get an absolute zero after switching barrels. This is a more realistic use case and more in line with the military's perspective on the MRAD acquisition. 338 Mag for material targets, 300 Mag for anti personnel and 308 for practice on ranges that don't support the 300 Mag.
Personally, I fall into the second batch and will probably only have 2 or 3 barrels (this simplifies the suppressor side too). I had not thought about the hunting application in Africa but that sounds fantastic too. I'd love a 300 Norma that is a hammer and a 308 barrel so I'm not shooting $5 bills every time I pull the trigger. Maybe a 338 and 6.5 or 6mm will happen but I want to actually shoot this rifle.
@newguy2k3v2 I really like that idea, could you post a pic of it to help visualize? How repeatable do you find the barrel switch to be? Do you land within 0.2-0.5 MIL or how repeatable is your system?
As these systems become more mainstream, I hope more scope manufacturers figure out the legit toolless zero reset. Apart from TT I'm not sure anyone else is doing that?