check out 8541 Tactical's return to zero test of the ADM Recon scope mounts. The general consensus is that they will return to zero, but the first shot may be a hair off as the mount gets settled into the forward part of the rail.
I own the ADM-Recon and have found similar results. The mount and scope is shared between my 260/308 switch barrel, and 2 22's and I have recorded the offset and scope settings for each gun. I haven't had any problems with swapping guns, dialling the applicable elevation/windage correction for that particular rifle, and being zeroed within two shots. As his test shows, my first round is within .5moa of the original zero, and the second round is on zero.
I can't speak for other brands or QD rings vs a complete mount. My thought would be a mount would be more consistent than 2 independent rings.