I have no experience with H1000, but I have seen higher pressures with several powders than QuickLOAD predicts.
I now start on a lower node, chronograph the velocity and adjust the burn rate of the powder so QuickLOAD's prediction matches the actual velocity. Only then do I move to a higher node.
The QuickLOAD user manual is useless, but it does warn that powder burn rates can vary 10% or more. I have yet to find a powder that produced higher velocity than QuickLOAD predicts. There does seem to be a bias in the wrong direction.
H2O capacity of a fired case has a similar effect.
Having said that, I do find QuickLOAD to be a useful tool. It is, however, very much a black box where the output is very much a function of the input.
Good luck.