The top of the top... rarely if at all move their tuners once tune is astablished.
Of course they don't... neither do I... once you've set it up to optimize for a type/velocity of 22LR ammo, there's no reason to. But adjustment would likely make a difference if you change from, say Lapua Center-x/Midas+ to the Eley family of ammo.
Anyway, I could go on, but detailed tuner discussions belong in a different thread, not this Vudoo Bolt Action thread! ;-)