I use a 21st century hydro bullet seater, arbor press and Wilson and Sinclairs new inline seaters.
Diver is correct that you have an increased level of feel compared to a, normal single stage press and it will give you better feedback about seating pressure, witch will let you sort out any abnormities, and can actually tell you a bit about your reloading procedures and they're effect in some cases. And it does not only tell you about neck tension, it can be other factors that gives you a higher amount of seating force.
Currently i think that the 21st century, hydro bullet seater and the direct leverage arbor are the best out there.
The hydro seater gives an actual reading of seating pressure in PSI instead of doing it by feel so it is more accurate, then a normal arbor press.
K&M also has a similar model but the 21st version is in my opinion a better product that gives more accurate readings, mostly due to it's design, it also costs more though.
I do sort my loaded ammunition by seating pressure and it helps reduce my sd/es by doing so.
And i have found for my rifles they seem to produce the best es/sd numbers when seating pressure on the press is between 25 and 40 PSI.
As for runout if you use a good single stage press and threaded dies, there will normally not be much difference between them.
I do not believe you will notice any useful accuracy difference with half a thousand extra runout.
But having the wrong neck tension for your rifle, or big variances can produce a large difference at longer range at least.
As for the protability yes the arbor system is easier to move around if you only load on the range, then a traditional big single stage press can be a bit inconvenient and for such a purpose i'd buy a Harrel's precision press if using threaded dies.
So there is not all that much to gain there either.
Another point for me when choosing to use a arbor press and inline seaters is that i do my sizing and seating in two different operatoions and it saves me time when reloading, at least the way i do it.