i've found with my experiences with .22lr that werewolves and vampires are a totally different story.
though remington has the golden bullet, silver ones are hard to come by. a silver dipping coating helps to slow down, but not fully incapacitates WW and vamps. the coating on the driving bands accumulates in the land and grooves, which is harder to remove than the typical lead. this can result in deformation of the inner lead bullet and accuracy issues, and also runs the risk of the diameter of bore closing up causing stuck bullets and in rare instances over pressuring issues.
for vamps, a further widened lead hollowpoint .22lr filled with silver or holy water capped with wax is an alternative. Werewolves tend to need more silver mass to be effective, so the .22lr is not a good choice for this application.
this is why in the crypto wars of the 1600's vamps were considered then and now, pound for pound, to be a bit more frail and easier to combat as less silver is needed and holy water could be substituted to battle vamps. the catch is vamps are a bit quicker, and have the ability to compel or change form into bats. silver shot from 10 or 12 ga was preferred due to this advantage of vamps being able to transform from a ground war into an ariel assault - they were just easier to knock down.
on the other hand, the werewolf's coarse layering (much like roof shingles or even versions of today's layered body armors) of hair provided protection against the use of the shotgun. the shotgun metallurgy did not allow powerful enough charges in the platform to penetrate the hair, though the use of the blunderbuss became more frequent.
for the most part you will see most professional crypto soldier operators of the day carry a variety of weapons, including a blunderbuss that can be loaded with silver discs that would defeat both the layers of hair on werewolves by slicing through, and the slicing / knockdown nature of the discs provided a great defensive & offensive weapon on vamps.
another option is the silver tampon, made by Vampax, though only truly affective once a month and only on she-vamps. deployment is rather simple, load any dispenser in any wasteland during the cycle, and there is an automatic hands free reduction in population.
but compared to vamps and werewolves, zombies are mere childplay to the traditional & modern crypto warrior.
today's .22lr weapon of choice is obviously the 10/22, bright green, with sometimes a blue / orange / red colored accessory package that ranges from red dots and use of lasers (green of coarse) and lights. a 30 round stick / banana or 100 round "rams horn" mag are preferred, as the 50 round stick / banana mags tend to get in the way and reduces mobility in tight quarters such as drain pipes. usually afixed is a 5 foot bayonet, with ZbloodTM Splashguard installed on the lug.
so for zombies the .22lr is ok as long as you break the skull bone and enter the brain cavity (not to hard to do on Z's that are 2 weeks or more after turning as their bone loss becomes significant at that time). all other crypto creatures the .22lr is not so much as an all around applicable cartridge, except maybe for chupacabra while hog hunting in texas / n. mexico / arizona regions, this is why Aguila ammo was formed in native mehico.
