I do all my comparisons apples to apples as close as possible:
16" Grendel vs. 16" 6.8
123gr SST vs. 120gr SST
Factory load vs. factory load
The 6.5 123gr Hornady SST vs. the 6.8 120gr SST is about as close as you can get apples to apples. I've compared several different bullets and weights for both, but there really wasn't anything that close until these two loads. 6.5 Grendel Nosler AB's were always heavier, and the lightest Barnes TTSX for the 6.5 is a 100gr designed around faster cartridges, but still performs great from the Grendel. The 115gr Barnes wasn't the same type of bullet at all as the 115gr OTM or Pro-Hunters. Now that there are two SST's of comparable weights within 3gr of each other, it makes it much easier for the discerning consumer.
What advantages does the 6.8 have over the 6.5 out to 300yds?
Trajectory?
Wind deflection?
The factory 123gr SST leaves the 16" Grendel barrel at 2350fps according to Hornady. The 16" 6.8 spits the factory 120gr out at 2460fps. By 200yds, the Grendel has already exceeded the 6.8's energy. A .510 BC pill will cut the wind better than a .400 BC pill all day long as well, so your hit probability is much better with a Grendel-rules of the road. From 200yds on out, the Grendel will continue out-gassing it, and will still penetrate deeply through game, with double caliber expansion with the SST.
Hornady Manufacturing Company :: Ammunition :: Rifle :: Choose by Caliber :: 6.8mm SPC :: 6.8mm SPC 120 GR SST®
Hornady Manufacturing Company :: Ammunition :: Rifle :: Choose by Caliber :: 6.5 Grendel :: 6.5 Grendel 123 gr SST®
If you want to make the comparison more fair for the 6.8, use a 14.5" Grendel and an 18" 6.8 to keep the energies similar out to 400yds. I've run comparisons ad-infinitum between the two because I used to believe the claims that you needed a 24" Grendel to be competitive with the 6.8. The fact is you need an 18" or 20" 6.8 to try to be competitive with a 14.5" or 16" Grendel for wind drift and energy past 200-300yds.