Both are great rounds in a small block AR, IMO. I went with the Valkyrie and my Dad went with the Grendel. He went with the Grendel because he has a Howa mini in 6.5 that he loves. I went with 224V because I was already set up to shoot it, 6.8 bolts, mags, brass, etc.
It depends what your going to use it for. I went Valkyrie because it was going to be cheaper for me to reload and shoot. I use it for target shooting and coyotes. Both cartridges require a change of bolt, barrel and magazine to run in an AR. 224V is based on the 6.8spc, the Grendel on the 7.62x39.
If your going to be starting from scratch, just read up on both and see which one fits your budget and intended use. The 6.5 is an amazing round, its established and it shoots. The 224V is still kinda new on the scene, I love mine. I dont regret going Valkyrie. It's a 20", 1:6.5 twist, stabilizes 88ELDs and 90SMK.
If you go Grendel, I recommend the: "6.5 Grendel II" chamber. It's an updated chamber spec from the original so if you go that route, keep an eye out on the specs of the upper/barrel you buy and get the Grendel II chamber. If you go Valkyrie, I would shoot for a 1:6.5 or 1:6 twist if you want to run 90gr plus bullets. I had a 1:7 twist CMMG 24" barrel first. It did ok with the 88ELDs but just didnt like any 90gr or 95gr I loaded for it. I went to a 20", 1:6.5 twist, I love it. It handles better and shoots the 90s... finally.