It really just depends on how much internal adjustment the scope has and how short a range you plan to zero at. I have two different 22LR rifles, both set up with identical base/ring/scope set-ups. EGW 20-MOA rails along with Burris Signature Zee rings with another 20-MOA worth of inserts (total of +40-MOA) and wearing SWFA SS 10X scopes. Since the SS 10X has a ton of internal adjustment, getting even a 25yd zero is no issue and yet allows me to get way out there (for a 22LR) with HV ammo and pretty darned far with subsonic rounds.