You've got some things wonky. The base won't change the dope, just how much up is left in your turret on that 1000yrd shot. Your zero being at 300 is highly questionable. There's only a couple good reasons to use anything but a 100yrd zero. If you're just yeeting metal nuggets at steel plates at long range then there's really no good reason to use a 300yrd zero.
So to expound on your actual question: If you need 21moa to boop the snoot of a 1000yrd distance target with a 0MOA base then you'll need 21moa with a 20moa base. Where the difference lay is if you dial in 21moa on the current setup and you have, as an example only, 25moa of up remaining then replacing your 0MOA base with a 20MOA base will mean you now can dial your 21moa of up and you'll have 45moa of up remaining.
Pick your base cant angle based on what distance you shoot and the required up to get there. You want to not have the turrets spun to their extreme limits up or down because that is the worst place, optically speaking, for it to be.