Man...take this from a guy that loves the 22-250 for whats made for...Varmints period. If you want to shoot targets at range beyond 600 meters use another caliber. The 22-250 is a 1/14 twist to a 1/12 twist rifle. I know I once thought about what your doing.
Ill save you allot time also, if you want to shoot paper or varmints at 600 meters (which is pretty much the max reliable precision for the 22-250) settle on just one bullet that shoots well.
For my experience that bullet is a Sierra .22 caliber 53 grain HP match. Its versatile as heck and the only way to go for coyotes, bobcats, prairie dogs and paper fun at the range to 600 yards. No matter what I shot over the last 58 years from a .223 through 6mm, I always come back to the 22-250 and 53grain Sierra Match HP.
"As or whats my favorite load for the 53 ?" For that Ill get on my soap box and lecture: "I wish folks on the internet would stop asking that statement period. Why? because there is more to powder, primers and cases when reloading. There's the rifle for one and barrel metal harmonics. There's BC and range being loaded for as another, and there is the environment. " Okay I stepped down. Hahah
Do what your taught, setup you case correctly paying particular attention to various headspace and neck diameters as they relate to friction for your rifle. Play with land numbers if you may...but I bet you;ll find your best seating depth is the one right for you rifle and load as long as its not jammed which is dangerous is you do what so many wrongfully do and "pack the powder high" As Cortina suggest...Stop Chasing the lands. Then start at minimum powder load and work your way up. Keep good notes and compare to paper target performance. Always remember this ..."its not how fast the bullet goes or how heavy the bullet is to buck the wind, its how repeatable the bullet strike is all the time at midrange.'
You see by picking the right bullet and knowing ballistics you'll soon discover the 22-250 is versatile tom 600meters without any mods unless you wildcat it. Believe me when you can learn to shoot very well at 500yards with it...you'll know what all these words are about!