To the OP:
If you shoot 22LR through a suppressor, lead build-up will happen. Period.
The amount of build-up depends on the amount of use. More use, more build-up.
If the suppressor was designed for a .308, when you go back and shoot that same can, with build-up, with a .308 again, the pressure "might" knock some of that build-up free. If it's teeny-tiny pieces, then you won't even notice. If it's big ol' chunks, then those chunks "might" get in the way of the next round. "Might" cause a strike, "might" not. If you had shot so much 22LR through it that the effective bore size was reduced below .308 tolerances, then your first .308 round will touch the build-up. It "might" deflect the round enough to cause a strike, it "might" not. Chances are better that it will cause a POI shift. If you try your best to soak-or-ultrasonic clean the can after the 22LR, you "might" get most of the build-up free, but you also "might" have just made it easier for some big chunks to break loose when the first .308 pressure does it's magic.
Notice all of the "might"s in that explanation? It means it is a Definite POSSIBILITY, but it DEPENDS on Your use and circumstances.
Zak is correct.
KYS is correct.
816Gump, *sigh*, is correct (but vehemently trying to not pay the $100 foot-in-mouth-braggart-Tax he signed up for)...
As Graham already succinctly pointed out: yes, it's physically possible to do, but no, it's not the best option.
Even Zak recommends a dedicated 22LR can if you're going to use it "a lot". There's a reason: shit happens. Why set yourself up for failure?
-out...
If you shoot 22LR through a suppressor, lead build-up will happen. Period.
The amount of build-up depends on the amount of use. More use, more build-up.
If the suppressor was designed for a .308, when you go back and shoot that same can, with build-up, with a .308 again, the pressure "might" knock some of that build-up free. If it's teeny-tiny pieces, then you won't even notice. If it's big ol' chunks, then those chunks "might" get in the way of the next round. "Might" cause a strike, "might" not. If you had shot so much 22LR through it that the effective bore size was reduced below .308 tolerances, then your first .308 round will touch the build-up. It "might" deflect the round enough to cause a strike, it "might" not. Chances are better that it will cause a POI shift. If you try your best to soak-or-ultrasonic clean the can after the 22LR, you "might" get most of the build-up free, but you also "might" have just made it easier for some big chunks to break loose when the first .308 pressure does it's magic.
Notice all of the "might"s in that explanation? It means it is a Definite POSSIBILITY, but it DEPENDS on Your use and circumstances.
Zak is correct.
KYS is correct.
816Gump, *sigh*, is correct (but vehemently trying to not pay the $100 foot-in-mouth-braggart-Tax he signed up for)...
As Graham already succinctly pointed out: yes, it's physically possible to do, but no, it's not the best option.
Even Zak recommends a dedicated 22LR can if you're going to use it "a lot". There's a reason: shit happens. Why set yourself up for failure?
-out...