They are as noisy às peacocks, everyone will hate you
I have heard that possums eat ticks.
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They are as noisy às peacocks, everyone will hate you
@diggler1833 is there anything like simperica trio (sp) that is safe for humans?
Maybe I'll just try something on myself...if I do, I'll let you know.Well... Nothing that has been reported on that I can find.
Maybe you should do a blind test on a relative you don't really like and let us know how it went.
That's a drag but there will always be drug interactions. Fortunately for us, and our dogs, we have never had any issue with Simparico Trio over the last 15-20 years. During that time we have lost 4 (old age and a puppy we don't know for sure what happened) and currently have 3. Just a couple of days ago was the dosage day. The Weiner Dogs just gobble that stuff down but my bird dog tries to fool us...chew air and then drop that tablet when he thinks we aren't looking. It won't have a single tooth mark. Don't believe folks when they tell you dogs won't lie! HAHA! I can usually just tell him no and to eat that but I ended up having to put it down his throat, hold his muzzle, stroke his neck and blow in his face. He finally swallowed. Now...the only resistance was not swallowing that pill. He is very compliant otherwise.
Grand mal (major) seizures, the most common in dogs, look pretty much the same, if not even more violent. Petit mal (minor) seizures on the other hand, can take on almost any form and are less common, but probably what you observed. The class of drugs which includes Simparica/Simparica Trio, Nexgard/Nexgard Plus, Bravecto, Credelio/Credielio Quatro, etc (isoxazolines) ALL come with a warning to use with caution in dogs with a history of seizures. The most likely explanation in your case is that it unmasked a subclinical form of epilepsy, especially if it was a younger dog (less than 5 yrs old). I have seen dogs with a history of seizures take these drugs with no problems, and others that it definitely affected - which matches the label to "use with caution", vs "contraindicated". You just don't know until you try it. Most of the time, we avoid using these with a history of seizures, unless the owner is fully-informed and still wants to go with it. Also most of the time, they still do fine, but not always. On the upside, they are incredibly effective -the most powerful tool we've ever had against fleas/ticks, and we see very few experience side effects. I'm sure you are aware that almost any drug ever produced has a website or twelve dedicated to how "deadly" it is, where most of the data presented is anecdotal and not clinically proven. While my experience may be different tomorrow, (and is also "anecdotal", since I'm not involved in a current clinical study) I can say that to date we have not seen a death directly attributed to isoxazolines since they were introduced (Nexgard was the first to market in 2013). Seizures - yes, but no deaths.. BTW dog seizures look nothing like human seizures -
Netherlands docs have done large studies on pharmacokinetics of above isoxazolines (sarolaner & afloxolaner) in humans specifically for addressing vector borne mosqituoes & sandfly diseases; I remember about something one dose providing efficacy for 50-90 days, but I have only seen handful of case reports/clinical trialls - I think sarolaner was used for drugs resistance human scabies. Case reports and small studies - not widespread use.@diggler1833 is there anything like simperica trio (sp) that is safe for humans?
She older - over 10, no history of seizures, has done Bravecto & Credilio without problems. Maybe related to her liver issues?Grand mal (major) seizures, the most common in dogs, look pretty much the same, if not even more violent. Petit mal (minor) seizures on the other hand, can take on almost any form and are less common, but probably what you observed. The class of drugs which includes Simparica/Simparica Trio, Nexgard/Nexgard Plus, Bravecto, Credelio/Credielio Quatro, etc (isoxazolines) ALL come with a warning to use with caution in dogs with a history of seizures. The most likely explanation in your case is that it unmasked a subclinical form of epilepsy, especially if it was a younger dog (less than 5 yrs old). I have seen dogs with a history of seizures take these drugs with no problems, and others that it definitely affected - which matches the label to "use with caution", vs "contraindicated". You just don't know until you try it. Most of the time, we avoid using these with a history of seizures, unless the owner is fully-informed and still wants to go with it. Also most of the time, they still do fine, but not always. On the upside, they are incredibly effective -the most powerful tool we've ever had against fleas/ticks, and we see very few experience side effects. I'm sure you are aware that almost any drug ever produced has a website or twelve dedicated to how "deadly" it is, where most of the data presented is anecdotal and not clinically proven. While my experience may be different tomorrow, (and is also "anecdotal", since I'm not involved in a current clinical study) I can say that to date we have not seen a death directly attributed to isoxazolines since they were introduced (Nexgard was the first to market in 2013). Seizures - yes, but no deaths.
So I almost lost my dog last week - she had seizures after Simparico trio. BTW dog seizures look nothing like human seizures - animal has trouble walking/ataxia, lifting head, tremors,very confused. Almost like she was really drunk or stoned. No drinking for two days - had to take a cup to her mouth for her to take sips, and 4 day to eat again. Not a breed that should have trouble (genetically) but she has had liver problems in the past year.
On further research someting like 6400 dogs in US have died from Simparico, and 1700 from Bravecto.
Netherlands docs have done large studies on pharmacokinetics of above isoxazolines (sarolaner & afloxolaner) in humans specifically for addressing vector borne mosqituoes & sandfly diseases; I remember about something one dose providing efficacy for 50-90 days, but I have only seen handful of case reports/clinical trialls - I think sarolaner was used for drugs resistance human scabies. Case reports and small studies - not widespread use.