Yes, I ran this reticle on a .338 Lapua that was built by H-S precision. My load was a 250 grain Sierra match king over 4831 Sc powder. The reticle was HV.5. I was able to work up a load that matched the reticle. It took time and patience, but it can be done. I was happy for a little while, until I wanted to start playing with 300 grain Bergers, then it was back to the drawing board and more load development. I was able to get another load to work with that as well. However.....I sold the scope and went with a straight MOAR reticle for the following reasons:
1. The velocity reticle only works under standard conditions, as weather changed, temp, humidity, elevation, etc. bullet impact changes, so the reticle is not spot on for long range 1000 yds + The loads that I developed in the summer were different in the winter due to basic weather changes.
2. I enjoy trying new bullets/ powder combinations and personally found it very hard to be married to one load.
3. I have switched to a very basic smart phone ballistics app, and find that the ability to dial in current weather conditions to the app, temp, humidity, elevation, etc. to be more accurate than the reticle, due to using real-time data.
4. Much more load flexability/ rifle flexability. I can switch calibers and not have to change reticles.
I know what you are thinking...wow wouldn't it be great to have e reticle match the load...no dialing...just hold and shoot !!! Well it really is not that simple. I found out with my own time and money. It can work if you are going to shoot under the same conditions all of the time and be married to a particular load....however I only married on thing in life....not room for anything else. Hope this helps.