Some points to consider when deciding if it would be better to use a canted rail or mount:
1. Does the scope manufacturer comment on it? From S&B's manual - "At the S&B factory the reticles of PM II scopes are adjusted out of center by half the amount of the full elevation range." Decide where you think most of the shots will be taken or the max range for the desired munition, and go from there. If the scope is set up from the factory to be in the range you expect most shots, no need for cant. If not, adjust accordingly.
2. How to decide if you need extra cant? As an example, 20 MOA cant gives you just under 6 mils. Will that work for or against you given the scope you use?
3. If by using cant on the rail or mount, would it keep the erector more in the center? Being a mechanical system, some believe that having the adjustments being closer to the middle of allowable range would provide more "even" tension on the erector and thereby more repeatable performance when making adjustments. The converse being, do you think that having both windage and elevation near or at the maximum of your scope would still provide the best repeatable performance when dialing in that range? Again from the S&B manual: "To get a consistent adjusting range ... the reticle on the scopes is usually set to the optical and mechanical center position."
4. For absolute max range of a weapon system using a PM II scope, I believe S&B recommends 45 MOA of cant. Depending on the ammo used, this should provide for a 100 yard zero and be able to use essentially all of the elevation the scope provides. From the S&B manual - "Mount the scope to the firearm and pre-adjust the scope to a target at 100 m distance using all adjustment facilities the mounts provide so that the least possible amount of elevation range must be used at the scope for fine adjustment."
5. Rule of thumb for deciding the maximum cant. Compute one half the total travel of the system and use that as the maximum cant. For example, the S&B PM II 5-25x has 26 mils of total travel. Therefore, 13 mils is the halfway point. If 1 mil = 3.438 MOA, then 13 mils = 44.7 MOA, and that's why S&B recommends (I believe) a 45 MOA cant.
The above are just some thoughts off the top of my head (and manual) concerning cant on a weapon system. If I am in error on anything I said, please let me know.