I'd set up a donor advised fund and dump a shit ton of money in there. Then I'd set up a series of real estate holding companies, buy a ton of short term rentals that qualify for a passive exception under the 7-day rule and have an engineering firm do cost segregation studies on all the properties so that I could write off a massive amount of depreciation to offset my winnings for tax purposes.
Once all that's squared away, I'd park the overwhelming majority of those properties in a SLAT or dynasty trust (at the direction of my attorney) and then secretly indulge in ungodly amounts of hookers and cocaine until my nose and/or penis falls off. Hopefully my nose.
We can dream....