McGowen, I assume...
Anyway, you can chamber and fit the barrel, and modify the boltface/bend the extractor for just about anything.
Getting it to feed from the mag is whole 'nother issue. I did a .44 mag once (pic below)- but it was a single-shot. Didn't even need to bush the boltface, but the case was way to short to mag feed. Guy just wanted something unique, for some target plinking (not that it wouldn't put a substantial hole in game).
The mag is single stack, and shaped specifically for the 54R case. Often the sides of the mag need to be cut out/modified- as well as some stock work inside- to try to make it work.
As noted, the ejector/interrupter would likely also need to be modified.
Google "Bannerman Mosin-Nagant" and you'll get an idea of what was done for the '06.
Fun and challenging for a guy that DIY's his own rifles- but when you get beyond "fit and chamber" into all the other shit needed it becomes an expensive proposition to pay a smith for the work, especially if he hasn't done it before and needs to spend the time to "figger it out".
If you want an interesting- and competitive- conversion/wildcat consider the 6.5 x 54R. Won the Olympic Biathlon. Will build one for myself if I can ever find the time, Manson has a print for it.