I've never seen extensive fragmentation from any bullets I've used for hunting. I generally use heavier bullets with no exposed lead and controlled expansion, or "ballistic tip" types. Neither has ever resulted in much fragmentation into the meat. I do restrict my shots to those that are through the ribs though. There's little heavy bone structure and I've never had a bullet fail to exit. It also saves on the extensive wound channels and tissue damage you might see with head-on shots. I end up throwing away the ribs because of the damage and the little usable meat.