I completely agree that the small sample sizes don’t tell the whole story. I thought I read somewhere on here that your SDx5 should be close to your ES if your data set is approaching a meaningful size….your aren’t even close. So, philosophically, I agree with everything said here. However, it’s possible that something else changed. Are you saying you shot five shots and had “good stats” and then a week later did everything the same and had “bad data”? Further, the good data was 6/10 and the bad was 20/60?
What I find hard to believe is that you found the best data set and then the worst, in two consecutive, same sample size, tests. It would be much more likely to be a case of “you got lucky” if your stats got worse by some smaller amount. So if you told us you shot three five shot groups and your sd/es data was all over a broad range or if you came back on session two and shot 20 rounds and your data went to shit. But to have terrific data followed by terrible (by a factor of 10) stretches the imagination for me. You MAY have encountered statistical outliers on the good and the bad end in consecutive tests but it’s possible you did something to make the problem worse.
Do you leave powder in the hopper? Was it a new jug that has now been open for a week. Do you calibrate your scale each time? Do you lube your mandrel and then do anything to wipe the lube out or to re-lube the necks if time has passed since mandrelling?
Just as an aside, I never get my most consistent velocities with virgin brass.