I can see Serena winning a single game of 3 sets; but I think there would have to be almost all unforced errors on the male pro's part. Again, top 100 would slaughter her. Though, now that I think about who's in the top 10 mens, I can see her 6-0,6-0,6-0. Top 100, maybe a game and that's with a ton of unforced errors.
Personally I couldn't imagine being on the other end of my court to my two tennis heros...Ivan Lendl or Novak Djokovic. The amount of top-spin they can generate on a serve is STAGGERING. I've seen what a former pro who was in top 200 could do and he actually REFUSED to serve it anyting over 50% to me!!!! That 50% was like HO LEE SHEEEUTTT!!!!!!!!!! (35 years ago...today...hell, serve it to me at 5% please)