In addition to what Krob said, there has been talk recently about Spuhrs causing binding in parallax adjustment(s). I have multiple Spuhrs on top end scopes and have never had that problem. I'm suspicious of the claim, but others say they have had issues, so, they must be having them.
I'd suggest maybe starting at 20 inch pounds for the screw caps and make sure you aren't having parallax adjustment problems. If the scope doesn't slip/move, leave them at 20. If the scope moves, increase to 25 inch pounds. I agree again with Krob, don't go above 25 inch pounds.
45 inch pounds on the rail clamps screws is fine.