Jumping in on the side of clean kills... I have hunted coyotes and hogs with both .308 (1:10) and 300BO (1:7) subs/suppressed. Like a lot of other posters have said, you have to be sure of your distances. All were 220 or 240 grain soft points at very short distances and were good kills. More than 20 years ago I had my single experience with having to track a whitetail over a long distance and then deliver a kill shot, all because I took a shot I shouldn't have and I knew it when I pulled the trigger. It is something I hope to never repeat. This may be my first year hunting whitetail sub/suppressed, and for whatever reason I am more concerned about making a clean kill with deer. Thanks for the info on bullet selection. I will need to do a bit of experimenting before deciding to use one on a hunt.