5.11 Tactical RUSH backpacks have a water-repellant coating on them and are pretty much fully covered in MOLLE. I have 2....a black one for every day, to and from work stuff and a flat dark earth one I pack all of my shooting stuff in for when I'm hunting paper in a field or woods. They are definitely tough. The black one I've had for a few years and used to switch my work stuff out for gun stuff and back and forth like that (hence why I bought a gun gear one) so its gotten tossed around a bunch and you can barely tell it's been used. As far as how water repellent though, I'm not sure. They've been sat in mud and damp ground and been out in the snow and mist and everything has stayed dry...I haven't dumped one in a creek or had one out in a full on rainstorm either though so I'm not sure. There are two water drainage grommets on the bottom, so if you think you're gonna be in some serious water, the water can come in through the bottom two holes....
Adam