POI will shift, and clocking can help, but dont expect it to eliminate it. Often the shift isn't enough to matter considering the short distances. I perfer the shift to be straight under sights, and that is how I clock it.
Remember also that if you clean the suppressor you start over. First shots from a clean suppressor, especially if a little oil was used, can be way off until burnt out.
If you want it for defense, clock it with your defense ammo, plinking ammo may be very different POI.