I've used 2000MR with the Juggernauts before and it was too temperature unstable for my liking. It will surely increase your MV, though! For a starting point, I would use Varget and work up from 43.0. Most people find a sweet spot somewhere around 44.0 but I've seen some people shoot it successfully at 45. In most instances, you will probably get a LOT of pressure signs at 45, unless you are using small primers. Start out jumping .020". The ideal twist for the 185s is 11, but you shouldn't have any issues with a 10.