A 52 grain Speer Hollow Point will not shoot through a coyote. If you are going to sell the fur, you will eventually find a load that you can settle on. With a 300 yard Zero, you will have to hold over, almost with any bullet. I sight mine in 1 1/2 inches high at 100, it is just a hair low at 300 and I use the lower duplex point at 400. Has worked for 30 years now on coyotes.
Sorry, I thought you were asking about a .22/250.