My 25" barrel 22 creed was running 3900fps with 60s, but I made it 180 rounds on prairie dogs before I was having bullets fragment after leaving the barrel.
I went all carbon barrels and the lightest chassis and stocks available for hunting. I have heavier bullets, but for now, 60 vmaxes are easy to get and I have a real good stockpile. So far, the past year, no coyotes needed a follow up shot using the 22 GT and I'm good with that. The other plus, it's a dedicated small rifle primer case and I have a good supply of primers from back when they were $23 per 1k