Hornady's new listing of their velocity banded BCs should help clue some stuff in
http://www.hornady.com/BC
they list 3 different BC numbers, for say, the 140 eld match
.646 above 2512 fps / .637 for 2512-2232 fps / .616 below 1953 fps
so if you take a standard 6.5 short action 140 load and say its moving @ 2750 fps...its using the highest BC (velocity above 2512 fps), until about 175 yds...BC doesnt matter much at all...its using the mid range BC until about 400 yds where its now moving 2200 fps...BC doesnt matter much here either, using .646 gives me 1.79 mil of drop while, using the lowest of .616 gives 1.81 mil of drop...somewhere around a whopping .25" difference...
now once its stretched out to 800 yds...if you were using the .646 BC, your predicted drop would be around 5.76 mil...the .616 BC yields 5.88...starting to diverge a little...
@ 1000 yds, .646 yields 8.35...616 yields 8.58
point of all this, truing by adjusting velocity until about 500 yds (600-800 if pushing higher BC bullets faster than the example), and then past that, resort to tweaking BC...it works well...if you try to just adjust velocity at your furthest target, its going to put you slightly high in your close/mid range...if you try adjusting BC in the mid/close range, its going to have to change so much, it throws off your long range...this will put you in the familiar place of a lot of guys who cant get their DOPE to line up across the entire supersonic flight...the ol "its .2 high at distance A, but dead on out at B" stuff you always hear, or i always hear at least...the BC and velocity work together and understanding how they jive will make your truing process smooth and easy, and like the above posters mentioned, multiple, repeatable hits at distance to verify, seen guys miss 3 times, then hit once, and call it good and move on...doesnt usually work out too well for them