I’d say the “unique characteristics” are of the same vein as the differences between a CC pistol and a USPSA carry optics legal pistol. Or between a hunting rifle and a prs rifle. Can I shoot an Sig 365 with an rmsc pattern optic in carry optics? Yes. Am I going to? No. Can I take my heavy prs rifle on an elk hunt? Yes. Do I have other rifles better set up for mountain hunting? Yes.
My neighbors in this suburban neighborhood are significantly less than 100 yards away. And, I'm having a hard time justifying the need to shoot even that far in a HD scenario. I mean, I'm not defending their house. Right? Maybe if someone is standing in the street (our house is at the end of a cul de sac) and lobbing rounds into my front door, but that's a pretty low probability.
Hey, if your HD scenarios require covering a 300 yard perimeter, set your gun up for that. My HD scenario is more like someone is trying to kick in the front door. For that, I think a red dot is optimal.
But, I don't enjoy shooting red dot equipped rifles. My range rifles have magnified optics, anything from 1-6x to 5-25x. Unless it is a specific trip to train with the HD gun, it is not what I am reaching for one I head to the range.
The above notwithstanding, I am contemplating a 1-8x lpvo with a top mounted reflex sight that might fit the bill for a HD/range gun.