that's the messaging as well as gun control is racist. These two points need to be marketed by GOA and NRA and others.
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that's the messaging as well as gun control is racist. These two points need to be marketed by GOA and NRA and others.
haven't seen anything on the overnight activities. Did the jackboots start rounding up the truckers?
Watching a live stream now... I don't see anything yethaven't seen anything on the overnight activities. Did the jackboots start rounding up the truckers?
Watching a live stream now... I don't see anything yet
LOUD AS FUCK!!!
I believe the local tow truck drivers are with the protest.haven't seen anything on the overnight activities. Did the jackboots start rounding up the truckers?
Even "emtional" Spock wasn't this illogical. The mere thought that this guy exudes shows he is completely fine with totalitarianism. So, maybe, somebody will show him his beliefs in person, so he can feel what it means to be completely at the whims of "his controller." Honestly the amount of stupidity right now is mind blowing. But, on the other hand, it confirms my belief that there really are not that many "smart" people out there - that the world itself is made of mindless automatons (IQ be damned).
Forgot the "Made in China" tag
Can this be presented in meme form? Asking for a friend…I honestly don't like the term "VAIDS" because it imply Vaccines cause the same immunodeficiency as advanced HIV; but mounting evidence is inferring there is some compromise of the immune system from both infection and vaccination. Papers need be done looking at effects on number and function of all WBCs (especially lymphocytes) pre- and post- infection and vaccination. The Lancet article cited by the "VAIDS" article online actually come to the conclusion the highest risk group should be boostered.
https://newstarget.com/2021-12-10-vaccine-induced-vaids-rising-mass-covid-vaccination.html
https://www.educationviews.org › vaccine-acquired-immune-deficiency-syndrome-vaids-we-should
This is the Lancet article frequently cited, but VAIDS isn't mentioned in the abstract.
Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study
34 Pages Posted: 25 Oct 2021
Peter Nordström
University of Umea - Unit of Geriatric Medicine
Marcel Ballin
University of Umea
Anna Nordström
University of Umea
More...
Abstract
Background: Whether vaccine effectiveness against Coronavirus disease 2019 (Covid-19) lasts longer than 6 months is unclear.
Methods: A retrospective cohort study was conducted using Swedish nationwide registries. The cohort comprised 842,974 pairs (N=1,684,958), including individuals vaccinated with 2 doses of ChAdOx1 nCoV-19, mRNA-1273, or BNT162b2, and matched unvaccinated individuals. Cases of symptomatic infection and severe Covid-19 (hospitalization or 30-day mortality after confirmed infection) were collected from 12 January to 4 October 2021.
Findings: Vaccine effectiveness of BNT162b2 against infection waned progressively from 92% (95% CI, 92-93, P<0·001) at day 15-30 to 47% (95% CI, 39-55, P<0·001) at day 121-180, and from day 211 and onwards no effectiveness could be detected (23%; 95% CI, -2-41, P=0·07). The effectiveness waned slightly slower for mRNA-1273, being estimated to 59% (95% CI, 18-79) from day 181 and onwards. In contrast, effectiveness of ChAdOx1 nCoV-19 was generally lower and waned faster, with no effectiveness detected from day 121 and onwards (-19%, 95% CI, -97-28), whereas effectiveness from heterologous ChAdOx1 nCoV-19 / mRNA was maintained from 121 days and onwards (66%; 95% CI, 41-80). Overall, vaccine effectiveness was lower and waned faster among men and older individuals. For the outcome severe Covid-19, effectiveness waned from 89% (95% CI, 82-93, P<0·001) at day 15-30 to 42% (95% CI, -35-75, P=0·21) from day 181 and onwards, with sensitivity analyses showing notable waning among men, older frail individuals, and individuals with comorbidities.
Interpretation: Vaccine effectiveness against symptomatic Covid-19 infection wanes progressively over time across all subgroups, but at different rate according to type of vaccine, and faster for men and older frail individuals. The effectiveness against severe illness seems to remain high through 9 months, although not for men, older frail individuals, and individuals with comorbidities. This strengthens the evidence-based rationale for administration of a third booster dose.
Funding: None to declare.
Declaration of Interest: None to declare.
Ethical Approval: This study was approved by the Swedish Ethical Review Authority (number 495/2021)
Keywords: Covid-19 infection, Vaccination
Suggested Citation:
Nordström, Peter and Ballin, Marcel and Nordström, Anna, Effectiveness of Covid-19 Vaccination Against Risk of Symptomatic Infection, Hospitalization, and Death Up to 9 Months: A Swedish Total-Population Cohort Study. Available at SSRN: https://ssrn.com/abstract=3949410 or http://dx.doi.org/10.2139/ssrn.3949410
This article just released on Friday from NEJM (biggest US journal) about autoimmune antibody potential rom both COVID infection and vaccination.:
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination
List of authors.
Metrics
- William J. Murphy, Ph.D.,
- and Dan L. Longo, M.D.
- Article
- Figures/Media
The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is incompletely understood, with its effects on multiple organ systems1 and the syndrome of “long Covid” occurring long after the resolution of infection.2 The development of multiple efficacious vaccines has been critical in the control of the pandemic, but their efficacy has been limited by the appearance of viral variants, and the vaccines can be associated with rare off-target or toxic effects, including allergic reactions, myocarditis, and immune-mediated thrombosis and thrombocytopenia in some healthy adults. Many of these phenomena are likely to be immune-mediated.3 How can we understand this diversity in immune responses in different persons?
Figure 1.Anti-idiotype Antibodies and SARS-CoV-2.
One way of thinking about the complexity of the immune response is through the lens of anti-idiotype immune responses. The Network Hypothesis, formulated in 1974 by Niels Jerne, described a mechanism by which the antibody responses to an antigen themselves induced downstream antibody responses against the antigen-specific antibody.4 Every antibody that is induced and specific for an antigen (termed “Ab1” antibody) has immunogenic regions, particularly in their variable-region antigen-binding domains, that are unique as a result of genetic recombination of immunoglobulin variable, diversity, and joining (VDJ) genes; VDJ recombination results in new and therefore immunogenic amino acid sequences called idiotopes, which are then capable of inducing specific antibodies against Ab1 antibodies as a form of down-regulation. A similar paradigm has been proposed for T cells. However, these regulatory immune responses are also capable of doing much more. The paratopes, or antigen-binding domains, of some of the resulting anti-idiotype (or “Ab2”) antibodies that are specific for Ab1 can structurally resemble that of the original antigens themselves. Thus, the Ab2 antigen-binding region can potentially represent an exact mirror image of the initial targeted antigen in the Ab1 response, and Ab2 antibodies have even been examined for potential use as a surrogate for the antigen in vaccine studies. However, as a result of this mimicry, Ab2 antibodies also have the potential to bind the same receptor that the original antigen was targeting (Figure 1). Ab2 antibodies binding to the original receptor on normal cells therefore have the potential to mediate profound effects on the cell that could result in pathologic changes, particularly in the long term — long after the original antigen itself has disappeared.
This aspect of regulation of immune-cell responses was postulated by Plotz in 1983 as a possible cause of autoimmunity arising after viral infection5 and has since been supported experimentally by direct transfer of anti-idiotype antibodies. Ab2 antibodies generated against the enterovirus coxsackievirus B3 in mice can bind myocyte antigens, resulting in autoimmune myocarditis,6 and anti-idiotype responses can act as acetylcholine receptor agonists, leading to myasthenia gravis symptoms in rabbits.7 In addition, by displaying the mirror image of the viral antigen, Ab2 alone can even mimic the deleterious effects of the virus particle itself, as has been shown with bovine viral diarrhea virus antigen.8
For SARS-CoV-2 infection, attention centers on the spike (S) protein and its critical use of the angiotensin-converting–enzyme 2 (ACE2) receptor to gain entry into the cell. Given its critical role in regulating angiotensin responses, many physiological effects can be influenced by ACE2 engagement.9 The S protein itself has a direct effect on suppressing ACE2 signaling by a variety of mechanisms and can also directly trigger toll-like receptors and induce inflammatory cytokines.10Anti-idiotype responses may affect ACE2 function, resulting in similar effects. However, preclinical and clinical assessments of antibody responses to SARS-CoV-2 vaccines have focused solely on Ab1 responses and virus-neutralizing efficacy. The delineation of potential anti-idiotype responses has inherent difficulties because of the polyclonal nature of responses, dynamic kinetics, and the concurrent presence of both Ab1 and Ab2 antibodies. Furthermore, ACE2 expression within cells and tissues can be variable. The different vaccine constructs (RNA, DNA, adenoviral, and protein) are also likely to have differential effects on Ab2 induction or in the mediation of vaccine effects that differ from responses to infection. Some off-target effects may not be directly linked to Ab2 responses. The association of thrombotic events with some SARS-CoV-2 vaccines in young women and the etiologic role of anti–platelet factor 4–polyanion antibodies may be the result of the adenoviral vector. However, the reported occurrence of myocarditis after vaccine administration bears striking similarities to the myocarditis associated with Ab2 antibodies induced after some viral infections.6 Ab2 antibodies could also mediate neurologic effects of SARS-CoV-2 infection or vaccines, given the expression of ACE2 on neuronal tissues, the specific neuropathologic effects of SARS-CoV-2 infection,11 and the similarity of these effects to Ab2-mediated neurologic effects observed in other viral models.
It would therefore be prudent to fully characterize all antibody and T-cell responses to the virus and the vaccines, including Ab2 responses over time. Using huACE2 transgenic mice and crossing them with strains that are predisposed to autoimmunity or other human pathologic conditions can also provide important insights. An understanding of potential Ab2 responses may also provide insights into Ab1 maintenance and efficacy and into the application of antibody-based therapeutic agents. However, much more basic science research is needed to determine the potential role idiotype-based immunoregulation of both humoral and cell-mediated responses may play both in antiviral efficacy and in unwanted side effects of both SARS-CoV-2 infection and the vaccines that protect us from it.
Disclosure forms provided by the authors are available at NEJM.org.
This article was published on November 24, 2021, at NEJM.org.
Author Affiliations
From the Departments of Dermatology and Internal Medicine, Division of Hematology and Oncology, University of California, Davis, Sacramento (W.J.M.).
I think they should do it. As the city burns it will melt all of that snow up there.
I put them out, along with the two links above, because most (at least 90%) much of the "reports"/articles I found on a quick search on VAIDS cite The Lancet article I put above over and over. The second article literally came out last Friday and is very useful in the autoimmune argument - but the problem is right now I think researchers are being pushed to group effects of infection and effects of vaccination together (i.e. given that they have started to come out about breakthrough infections - expect to see vaccination side effects being reported as COVID infection side effects).i tried to suffer through that post….the more i read, the more it seemed like propaganda bullshit. like we should believe anything that comes from these fucking fools anymore.
Then the oceans would rise and we'd have another global disaster on our hands...ROFL.I think they should do it. As the city burns it will melt all of that snow up there.
They missed an opportunity when they didn't put a "Made in China" label on that hat. Double burn.
Yes sure, but will he enforce it? No, he is a gigantic pussy, and wants someone with a gun to enforce it for him.
She's 52...but good for her.Today's Dagny Taggart of Atlas Shrugged:
Warren Buffett’s BNSF Railway Names Kathryn Farmer First Female CEO Of Major Railroad
Berkshire Hathaway’s BNSF Railway has appointed Kathryn M. Farmer as president and chief executive officer, effective January 1, 2021. In taking the top job, she will become the first woman to helm a major railway operator in North America.www.forbes.com
Heavily armed German police officers raid 'illegal' mask-free school started by parents - LifeSite
The children were separated from their parents and gathered on the second floor before being questioned individually for four hours.www.lifesitenews.com
tokenShe's 52...but good for her.
Somehow, that's not my picture of Dagny. .Today's Dagny Taggart of Atlas Shrugged:
Warren Buffett’s BNSF Railway Names Kathryn Farmer First Female CEO Of Major Railroad
Berkshire Hathaway’s BNSF Railway has appointed Kathryn M. Farmer as president and chief executive officer, effective January 1, 2021. In taking the top job, she will become the first woman to helm a major railway operator in North America.www.forbes.com
Somehow, that's not my picture of Dagny. .
Maybe she and Elon will hook up and give the government a run for their money.... Or be the founders of Galt's Gulch..... IDKWhy is she Dagney Taggert? Is she fighting government takeovers by communists of private industries?
Does she think you should only get paid and earn what you are worth in an open market?
Has she found an engine that will create propulsion from atmospheric static electricity?
If not, she's just a woman who's worked into that position.
I was just picturing her look; nothing about the ideals. Sorry, I guess I didn't make that clear. I pictured Dagny a little more like a brainy looking, yet supermodel looks, and obviously stylishly dressed, woman.Why is she Dagney Taggert? Is she fighting government takeovers by communists of private industries?
Does she think you should only get paid and earn what you are worth in an open market?
Has she found an engine that will create propulsion from atmospheric static electricity?
If not, she's just a woman who's worked into that position.
Well, you know, age takes it's tollI was just picturing her look; nothing about the ideals. Sorry, I guess I didn't make that clear. I pictured Dagny a little more like a brainy looking, yet supermodel looks, and obviously stylishly dressed, woman.
I was just picturing her look; nothing about the ideals. Sorry, I guess I didn't make that clear. I pictured Dagny a little more like a brainy looking, yet supermodel looks, and obviously stylishly dressed, woman.
Former sniper for Trudeau is coordinating volunteer security for truckers — The Counter Signal
Corporal Daniel Bulford, a former RCMP sniper who was fired for refusing to take the vaccine, has a new job: head of security for the Freedom Convoy.www.thecountersignal.com
Things that make you go hmmmmmm
Is that why femboy left town?
Lives in a bubble? A world all his own.
A true legend in his own mind.Lives in a bubble? A world all his own.