I have reloader 16 ,17,26, and 4350. I prefer reloader 16 and am about to try 26 with heavies. Have heard very promising things about 26. 17 is a little bit temp sensitive from my findings with my 308 running heavies. So I do not use that as much. 16 gave me a little bit better velocities over 4350 and both are not temp sensitive so have stuck with 16. I have reloader 26 for my 6.5 saum so will be loading up some of the new 144 berger hybrids and the Sierra 150s for the creedmoor and see if I can get another 50 to 100 fps.