I'll actually give you a fuller answer, because you generally aren't a dick. The answer to your question is yes, they are different. Significantly. But what you are really getting at is that Susan Collins and Joe Manchin are about the same, which totally makes sense since they are basically mirror images of each other. The base thinks, for some unknown reason, that they are going to get what they want, but they never do because the base isn't big enough to get a majority, so they rely on the median senator (or representative) who is representing their constituents, who are much more centrist, for that vote to pass legislation. So most legislation looks like something a Manchin or a Collins would support, and while those two things are different, they are not as different as the bases are. TLDR version -- you think Susan Collins represents you, but she realizes that she represents a very blue state, so you don't get what you want. Ted Cruz would be happy to give you what you want, but he doesn't have the votes.
On the other hand, the median voter in the states tends to be much closer to the base than the median voter nationally. For example, my state has huge majorities in its house and senate, 31-19 and 67-33 with no filibuster, so a lot can get done without jeopardizing majorities. Because, of course, if you lose your majority, it is the next guys turn. That is why state legislation is not only better legislation, but a weak central government, strong state system is better. It is also why, if you look at approval ratings, state governments tend to be really high and federal low. Because in the federal government nobody is really getting what they want. As an example, look at the current situation of the progressives, which really sounds exactly like the Republican base in making the comment you make above.
On the margins, though, some people are more affected by federal changes, especially if they are large taxpayers, because given the structure of government, and the filibuster, reconciliation allows for the most policy change, but that is limited to taxing and spending.