Surprisingly enough they don't open up very well at that range. They tend to just pencil through. But it's a big enough hole to get the job done.
The 22-250 is an excellent round for Coyotes, I use to use a 50grn nosler BT, they perform better than the vmax because of the thicker jacket and cup on the nosler. Today I prefer a larger round, 6SLR or 6.5saum.