Depends on the situation. Biggest thing I hunt is elk.
If I'm hunting thick timber or brush, I tend to carry my Winchester Featherweight 30-06 or my Browning BLR Lever Action .308, both highly effective, however I lose confidence beyond 300 yards.
If I anticipate taking a shot over 200 yards I tend to pack my 6.5 creedmoor, AR 10. Took two elk with it this year. Not as easy packing as my sporter rifles, weighs in at 13.5 lbs, but it's manageable.
If I think I may be taking anything beyond 800 yards I pack my 300 Win Mag, built on an AI chassis. It weighs 14.5 lbs, not a pleasure to carry but it's manageable. Last week I was packing it into the High Uintahs in Utah, expecting to possibly take a shot at an elk at over 1000 yards. Turns out I found them in the quakies, took a shot off-hand at 85 yards. It got the job done.