Codie, I can verify 100% that the mid-70 class bullets HAMMER at 275 to 280,000 rpm. 4" groups from magazine at 600...silver dollar potential at 300...that kinda thing.
I think you'd find that if you hit a prairie dog with a 77 SMK, 73 Berger, or 75 BTHP from a fast twist -250, it will be damned devastating.
Said bullets, or even 80s, are gonna make longer range hits a whole lot more achievable. No amount of speed makes that 50 Vmax cut the wind at 400 yards, and with the -250, it's not as though you are forced to "cruise" the heavies like I am.
Ideally, I'd go 9.5"-8.5" progressive 5R Bartlein at 22-24" in a light or medium Palma or a straight taper to 0.900" if you won't be carrying it. 26-28" if I meant ti spend a lot of time at 1,000 yards, but I doubt that's your plan.
If you need a straight twist, 1-8.0" is the call if you want assurance the 70s and 80s will work.
Honest: I've a stack of fake walnut and a lot of very sad coyotes that say you don't need two loads. And I'm just a knuckledragging .223 service rifle guy...at LEAST 300 fps behind you.
That 300 fps is worth about 25,000 rpm. I finish at about 6.6" on those loads, where you'd be near 8.0" to get the same revolutions on a mid-70 class bullet. Ie: totally copacetic at 8.5, or even 9 with a .22-250.
You're doing the right thing, pondering twist. Spend time on the dimendions of the reamer too. Call JGS.