fly to miami and drive all the way to key west, has to be the prettiest, most relaxing, stress-relieving drive/scenery in the world.
sanibel island on florida gulf is supposed to be the best shelling beach in the USA. ding darling national wildlife refuge on adjoining captiva island has amazing wildlife.
Only problem with that drive is that it's a single lane highway, and backs up like a motherfucker on weekends. Especially if you have weekend warriors with junk ass RV's breaking down on the side of the road.
The keys are really nice though.