Call Bighorn. Never had an issue igniting 450's in my 3 TL3's. Sounds like a trigger issue
My buddy sent his TL3 in to have the issue fixed. They modded the firing system and sent it back to him. Only issue is that the problem is still happening. The lot of 450s is bad, which is probably the case with most people that have issues with the 450s in this thread. When I talked to my gun smith about the issue, he told me about the fact that he had 15,000 that did the same thing in every weapon he tried them in. He tried to get CCI to correct the issue and they basically told him to pound sand (same thing they told me).
I suggest try the 205M or 205MAR primers.