Reading this, I guess I never actually replied to the premise of the thread, so I'll wade in with a controversial opinion:
.300blk in subsonic and supersonic
reasoning: if I'm shooting something farther away than 600m I'll just use a bolt gun, while inside that range the 300blk in supersonic is quite accurate and effective. up really close you can just use subsonics with a suppressor.
9" barrel platforms (MCX or custom AR) in .300blk with correctly tuned gas systems to allow the use of subsonic and supersonic with nothing but a simple magazine change have essentially killed the submachine gun concept. Or depending on your perspective have become the perfect fusion of the subgun and the carbine.
if I could only have one rifle and it had to be an AR caliber, it'd be a hard choice between .300blk or 6mm ARC