You just contradicted your own statement. While you may not prefer .45 ACP, that doesn't mean it isn't a good round for defense. In fact, regardless of the theoretical data comparisons between .45 ACP and your favorite handgun cartridge, 110 years of use, in hostile environments, by civilian and military personnel, indicate that it is a very effective close range round. Are there other rounds that are just as good? Of course, especially with modern bullet technology. In reality, all pistol rounds are inferior in a gun fight. A rifle is preferred, but not always available.
I keep a suppressed 300BLK, loaded with expanding subs, by the bed for home defense, because I can effectively clear my house and not have to worry as much about hearing damage, if I have to fire a round inside. In the unlikely event that circumstances dictate a need for a rifle round, a mag change is all that's required. I challenge anyone that breaks into my house to tell the difference between a center mass hit from a 300BLK and a .223/5.56. Dead is dead. If your preference is 5.56, or 45-70 for that matter, use that. But let's not act like the choices others make are invalid.