I have a Remington 700 VLS in .22-250. I purchased it back in the mid 90s. Since then I've put a KRG Whiskey 3 chassis, Timney Calvin Elite trigger and Vortex PST Viper 5-25X Gen II scope on it.
The rifle has taken a lot of groundhogs. The only problem is that the barrel twist is the 1:12. Which is too slow for heavier bullets. The maximum effective range that I've been able to shoot is 600 yards. Beyond that it's a matter of extreme luck if I hit a groundhog.
Right now, I have several thousand rounds loaded with 55 grain bullets. After those are all shot, I plan on putting a barrel with a twist of 1:9 to shoot heavier bullets.
Bergara is producing a rifle in .22-250 with the 1:9 twist. So there must be something to it or else a company like them wouldn't be making a rifle with fast twist rifling.
The advantage to a fast twist barrel in .22 caliber is obvious to all of us. The only problem you will have with a fast twist barrel is shooting the traditional light weight bullets. I don't plan on doing that as barrel life would be pretty short.
If I were you, I would re-barrel the rifle with a fast twist barrel and shoot the heavier bullets.
The 55 grain Hornady V-max has a B/C of .255 (G1) and the 88 grain ELD Match has a B/C of .545.
The V-max load in my rifle has been chronographed at 3625 FPS. That gives it a drop of 66 inches and drift in 10 MPH crosswinds of 45 inches at 600 yards.
Let's say I can push the 88 grain ELD at 2600 FPS out of my rifle with reloaded ammunition. According to JBM the drop on the bullet at 600 yards from my rifle would be about 97 inches; an increase of about 31 inches. That's the bad news and range estimation is critical. However, the wind drift for a 10 MPH crosswind compared to the lighter bullet is about 29 inches for a difference of 16 inches less drift.
The increased drop of the heavier bullet is the price that I'm willing to pay for less wind drift. That may not be acceptable for some folks but I'm use to shooting a .45-70 at those distances so anything flatter than that round is a big improvement for me
I would not advise anyone to purchase a new rifle in .22-250 but since I have a ton of brass, the rifle with all of it's upgrades, buying a new barrel and loading heavier bullets makes sense for me right now.