Why re-barrel a Grendel? That makes no sense to me. Hornady makes the same V/T round for the Grendel. It's not 62 grains like the 22 ARC, it's 100 grains (80 grains for the 6 ARC).It’d be a different bolt face.
I’ve never re-bolt-faced, but I suspect it’d be easier/cheaper to re-barrel a 6.5 Grendel.
I’m sure there are others here with a better qualified opinion.
A Grendel should probably shoot a 100 grain bullet close to 2900 from a 20-inch AR, and most definitely higher from a hand loaded bolt gun.
All this with better wind resistance and bigger impact on target than a .224, Great 'yote round IMHO. The bullet design will hold velocity longer as well.
Still, I love the idea of this 62gr 22 ARC on a suppressed AR. Prairie dog town eliminator .