There are also studies out that are showing some of these nano and micropastics are crossing the blood-brain barrier. That's bad juju.
Humans are continuously exposed to polymeric materials such as in textiles, car tires and packaging. Unfortunately, their break down products pollute our environment, leading to widespread contamination with micro- and nanoplastics (MNPs). The blood–brain ...
www.ncbi.nlm.nih.gov
Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be taken up by aquatic organism as well as by mammals. ...
www.ncbi.nlm.nih.gov
"Upon
ingestion (
Fig. 2B), N/M-Ps cause serious toxicity to various biological organisms including
macromolecules (DNA & gene damage, affected gene expression, and altered protein transcription),
organelle cells (altered cellular division, cellular toxicity,
apoptosis,
oxidative stress reaction, metabolism, increased calcium ions),
tissues (bone
osteolysis, inflammation, and fibrosis),
specific organs (carcinogenesis, altered feeding, changed metabolic demand, and energy reserves redistribution) (
American Chemical Society, 2023;
Hua et al., 2022;
Leslie et al., 2022;
Lin et al., 2022;
Liu et al., 2020;
Pontecorvi et al., 2023;
Rosellini et al., 2023), and
populations including animal and humans (reduced fertility, slower growth, and reduced population). The M-Ps have entered lymph (<150 μm),
portal vein (110 μm), inside organs (20 μm), and access to organs including translocation of the blood-brain barrier (BBB) and
placental barrier (up to 7%) (
Yuan et al., 2022).
Recently, N/M − Ps on interacting with the brain cell may cause primary and secondary
injuries which may affect the motor coordination function (dysregulated circadian motor activity),
damage nerve cells, increase
apoptosis,
neuroinflammation, and
hemorrhage in cerebellar tissue (sudden rupture of blood vessels), respectively (
Bogorad et al., 2019). These
adverse effects caused by N/M-Ps in the brain involve multiple pathophysiological pathways that are related to the pathogenesis of neurodegenerative disorders like stroke,
Alzheimer's disease (AD), and
Parkinson's disease (PD) (
Yin et al., 2022)."